Synthetic Toxicology: Where Engineering Meets Biology and Toxicology
نویسندگان
چکیده
منابع مشابه
Synthetic biology meets tissue engineering
Classical tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or by allowing cells to self-organize into organs as they do during fetal life. Fo...
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Metabolic pathways can be engineered to maximize the synthesis of various products of interest. With the advent of computational systems biology, this endeavour is usually carried out through in silico theoretical studies with the aim to guide and complement further in vitro and in vivo experimental efforts. Clearly, what counts is the result in vivo, not only in terms of maximal productivity b...
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We propose the term "synthetic tissue biology" to describe the use of engineered tissues to form biological systems with metazoan-like complexity. The increasing maturity of tissue engineering is beginning to render this goal attainable. As in other synthetic biology approaches, the perspective is bottom-up; here, the premise is that complex functional phenotypes (on par with those in whole met...
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in december 2015, the world health organization (who) published the first ever report on the estimates of the global burden of foodborne diseases, which included diseases related to chemical exposures in foods such as peanut allergy. in the report, the burden of disease related to peanut allergies was measured for the european, american and west pacific regions. the report showed that unlike ot...
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The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. S...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2010
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfq339